A Trial to Find Out if REGN4336 is Safe and How Well it Works Alone and in Combination With Cemiplimab or REGN5678 for Adult Participants With Advanced Prostate Cancer

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

370

Participants

Timeline

Start Date

November 30, 2021

Primary Completion Date

January 14, 2027

Study Completion Date

January 14, 2027

Conditions
Metastatic Castration-resistant Prostate Cancer
Interventions
DRUG

REGN4336

Administered once weekly (QW) by subcutaneous (SC) injection, or intravenous (IV) infusion

DRUG

Cemiplimab

Administered concomitantly every 3 weeks (Q3W) by IV infusion

DRUG

REGN5678

Administered concomitantly QW by IV infusion

DRUG

Sarilumab

Administered once by IV infusion as prophylaxis prior to REGN4336 IV

Trial Locations (13)

14263

RECRUITING

Roswell Park Cancer Institute, Buffalo

19104

RECRUITING

Penn Medicine University of Pennsylvania Health System, Philadelphia

19107

RECRUITING

Thomas Jefferson University Hospital, Philadelphia

19111

WITHDRAWN

Fox Chase Cancer Center, Philadelphia

RECRUITING

Fox Chase Cancer Center, Philadelphia

21201

RECRUITING

University of Maryland Greenebaum Cancer Center, Baltimore

28204

RECRUITING

Atrium Health Levine Cancer Institute, Charlotte

40207

RECRUITING

Norton Cancer Institute, Louisville

43210

RECRUITING

The Ohio State University James Cancer Hospital, Columbus

53226

RECRUITING

Medical College of Wisconsin, Milwaukee

77030

RECRUITING

MD Anderson Cancer Center, Houston

94304

RECRUITING

Stanford University Medical Center - Blake Wilbur Drive, Palo Alto

08901

RECRUITING

Rutgers Cancer Institute of New Jersey, New Brunswick

All Listed Sponsors
lead

Regeneron Pharmaceuticals

INDUSTRY