Phase 2 Study of 9-ING-41 With Chemotherapy in Sarcoma

PHASE2WithdrawnINTERVENTIONAL
0
Timeline

Start Date

March 1, 2022

Primary Completion Date

August 1, 2025

Study Completion Date

August 31, 2030

Conditions
Soft Tissue SarcomaUndifferentiated Pleomorphic SarcomaMyxofibrosarcomaLeiomyosarcomaLiposarcomaAngiosarcomaSynovial SarcomaRhabdomyosarcomaSpindle Cell SarcomaHigh Grade SarcomaBone SarcomaOsteosarcomaEwing Sarcoma of Bone
Interventions
DRUG

Gemcitabine

Patients will receive 9.3 mg/kg 9-ING-41 twice weekly with 900 mg/m2 gemcitabine on days 1 and 8 and 75 mg/m2 docetaxel on day 8 of a 21-day cycle until disease progression or unacceptable toxicity.

DRUG

9-ING-41

Patients will receive 9.3 mg/kg 9-ING-41 twice weekly with 900 mg/m2 gemcitabine on days 1 and 8 and 75 mg/m2 docetaxel on day 8 of a 21-day cycle until disease progression or unacceptable toxicity.

DRUG

Docetaxel

Patients will receive 9.3 mg/kg 9-ING-41 twice weekly with 900 mg/m2 gemcitabine on days 1 and 8 and 75 mg/m2 docetaxel on day 8 of a 21-day cycle until disease progression or unacceptable toxicity.

Trial Locations (2)

02903

Hasbro Children's Hospital, Providence

Lifespan Cancer Insitute, Providence

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Actuate Therapeutics Inc.

INDUSTRY

lead

Brown University

OTHER