A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Melanoma (Morpheus-Melanoma)

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

110

Participants

Timeline

Start Date

February 2, 2022

Primary Completion Date

September 22, 2023

Study Completion Date

May 28, 2024

Conditions
Melanoma
Interventions
DRUG

Nivolumab

Nivolumab will be administered at a dose of 3 mg/kg IV on Day 1 of each 21 day cycle.

DRUG

Ipilimumab

Ipilimumab will be administered at a dose of 1 mg/kg by IV on Day 1 of each 21 day cycle.

DRUG

RO7247669 2100 mg

RO7247669 will be administered at a dose of 2100 mg by IV infusion on Day 1 of each 21 day cycle.

DRUG

Atezolizumab

Atezolizumab will be administered at a dose of 1200 mg IV on Day 1 of each 21 day cycle.

DRUG

Tiragolumab

Tiragolumab will be administered at a dose of 600 mg IV on Day 1 of each 21 day cycle.

DRUG

RO7247669 600 mg

RO7247669 will be administered at a dose of 600 mg by IV infusion on Day 1 of each 21 day cycle.

Trial Locations (14)

2060

Melanoma Institute Australia, North Sydney

13005

Hopital de la Timone, Marseille

20141

Istituto Europeo Di Oncologia, Milan

31059

Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse

33612

Moffitt Cancer Center, Tampa

53100

Azienda Ospedaliera Universitaria Senese, Siena

75475

APHP - Hospital Saint Louis, Paris

77030

MD Anderson Cancer Center, Houston

80131

Istituto Nazionale Tumori Fondazione G. Pascale, Napoli

90025

The Angeles Clinic and Research Institute - W LA Office, Los Angeles

91010

City of Hope, Duarte

94805

Institut Gustave Roussy, Villejuif

06132

Ospedale S.Maria della Misericordia, Perugia

08035

Hospital Universitario Vall d Hebron, Barcelona

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY