Anti-PD-1 and VEGF Bispecific Antibody AK112 in Combination With Chemotherapy in Patients With ES-SCLC

PHASE1CompletedINTERVENTIONAL
Enrollment

35

Participants

Timeline

Start Date

March 29, 2021

Primary Completion Date

December 4, 2023

Study Completion Date

December 4, 2023

Conditions
SCLC, Extensive Stage
Interventions
DRUG

AK112

IV infusion

DRUG

Etoposide

Etoposide intravenous infusion was administered at a dose of 100 mg/m\^2 on Days 1, 2, and 3 of each 21-day cycle during the induction phase (Cycles 1-4).

DRUG

Carboplatin

Carboplatin intravenous infusion to achieve an initial target AUC of 5 mg/mL/min was administered on Day 1 of each 21-day cycle during the induction phase (Cycles 1-4)

Trial Locations (1)

021

Shun Lu, Shanghai

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Akeso

INDUSTRY