Effects of Tildrakizumab on Epigenetic Age

PHASE4CompletedINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

April 8, 2022

Primary Completion Date

May 24, 2024

Study Completion Date

May 27, 2024

Conditions
PsoriasisAgingEpigenetic DisorderInflammation; Skin
Interventions
BIOLOGICAL

TILDRAKIZUMAB

"ILUMYA (tildrakizumab-asmn) is a humanized IgG1/k monoclonal antibody that selectively binds to the p19 subunit of IL-23 and inhibits its interaction with the IL-23 receptor. IL-23 is a naturally occurring cytokine that is involved in inflammatory and immune responses.~ILUMYA injection for subcutaneous use is a sterile, clear to slightly opalescent, colorless to slightly yellow solution supplied in 1mL single-dose prefilled syringe which contains 100 mg of tildrakizumab-asmn formulated in: L-histidine (0.495 mg), L-histidine hydrochloride monohydrate (1.42 mg), polysorbate 80 (0.5 mg), sucrose (70.0 mg), and Water for Injection, USP with a pH of 5.7-6.3. ILUMYA is supplied in a single-dose prefilled syringe with a glass barrel and 29-gauge fixed, 1/2-inch needle."

Trial Locations (1)

02903

Clinical Trials Center for Skin Diseases: Rhode Island Hospital, 593 Eddy Street, Dermatology Research, Jane Brown Building, 1st floor, Room 115, Providence

All Listed Sponsors
collaborator

Sun Pharmaceutical Industries Limited

INDUSTRY

collaborator

Brown University

OTHER

collaborator

Lifespan

OTHER

collaborator

Ocean State Research Institute, Inc.

OTHER

lead

Carlos Wambier

OTHER