Terazosin and Parkinson's Disease Extension Study

PHASE2RecruitingINTERVENTIONAL
Enrollment

15

Participants

Timeline

Start Date

September 23, 2022

Primary Completion Date

November 1, 2025

Study Completion Date

November 1, 2025

Conditions
Symptomatic Parkinson DiseaseREM Sleep Behavior DisorderPre-motor Parkinson's Disease
Interventions
DRUG

Terazosin therapy

Primary procedures in this study are MIBG scan, DAT scan, NM-MRI, and terazosin titration. Subjects will return for research visits and imaging every six months for three years. The investigators hypothesize that the rate of decline in DAT scan123I-Ioflupane uptake will be slower in subjects who have received the a1- Adrenergic Receptor Antagonist Terazosin, resulting in a decreased clinical conversion rate to parkinsonism.

Trial Locations (1)

90048

RECRUITING

Cedars Sinai Medical Center, Los Angeles

All Listed Sponsors
lead

Cedars-Sinai Medical Center

OTHER