A Study of Donanemab (LY3002813) Compared With Aducanumab in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 4)

PHASE3CompletedINTERVENTIONAL
Enrollment

148

Participants

Timeline

Start Date

November 16, 2021

Primary Completion Date

September 9, 2022

Study Completion Date

September 19, 2023

Conditions
Mild Cognitive Impairment (MCI)Alzheimer Disease
Interventions
DRUG

Donanemab

Participants received 700 milligram (mg) donanemab administered by intravenous (IV) infusion every 4 weeks (Q4W) for first three doses and then 1400 mg IV Q4W.

DRUG

Aducanumab

Participants received aducanumab administered by IV infusion per US label (prescribing information/routine clinical practice).

Trial Locations (31)

19001

Abington Neurological Associates, Ltd., Abington

19046

The Clinical Trial Center, LLC, Jenkintown

23294

National Clinical Research, Inc, Richmond

31909

Columbus Memory Center, PC, Columbus

32159

Charter Research - Lady Lake, Lady Lake

32216

Jacksonville Center for Clinical Research, Jacksonville

32751

ClinCloud - Maitland, Maitland

32789

Conquest Research, Winter Park

32940

ClinCloud - Viera, Melbourne

32952

Merritt Island Medical Research, LLC, Merritt Island

33024

Infinity Clinical Research, LLC, Hollywood

33125

Optimus U Corporation, Miami

33176

Brainstorm Research, Miami

33445

Brain Matters Research, Delray Beach

33462

JEM Research Institute, Atlantis

33609

Axiom Clinical Research of Florida, Tampa

33912

Neuropsychiatric Research Center of Southwest Florida, Fort Myers

34997

Brain Matters Research, Stuart

45459

Neurology Diagnostics, Inc., Dayton

46256

Josephson Wallack Munshower Neurology, PC, Indianapolis

63005

Clinical Research Professionals, Chesterfield

75231

Kerwin Medical Center, Dallas

89113

Las Vegas Medical Research, Las Vegas

91403

California Neuroscience Research Medical Group, Inc., Sherman Oaks

92614

Irvine Clinical Research, Irvine

92835

Neurology Center of North Orange County, Fullerton

06510

Institute for Neurodegenerative Disorders, New Haven

02360

Donald S. Marks M.D., P.C., Plymouth

02472

Adams Clinical, Watertown

07081

The Cognitive and Research Center of New Jersey, Springfield

08755

Advanced Memory Research Institute of New Jersey, Toms River

All Listed Sponsors
lead

Eli Lilly and Company

INDUSTRY

NCT05108922 - A Study of Donanemab (LY3002813) Compared With Aducanumab in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 4) | Biotech Hunter | Biotech Hunter