Extending the Time Window for Tenecteplase by Recanalization of Basilar Artery Occlusion in Posterior Circulation Stroke

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

688

Participants

Timeline

Start Date

November 29, 2021

Primary Completion Date

August 31, 2026

Study Completion Date

December 31, 2026

Conditions
Basilar Artery Occlusion
Interventions
DRUG

Tenecteplase

Genetically modified tissue plasminogen activator at a dose of 0.25mg/kg given as an intravenous bolus over 5-10 seconds.

DRUG

Standard Care (which may include intravenous Alteplase)

Patients will receive standard care which may include intravenous alteplase at the standard licensed dose of 0.9 mg/kg up to a maximum of 90mg, 10% as a bolus and the remainder as an infusion over 1 hour.

Trial Locations (13)

4102

RECRUITING

Princess Alexandra Hospital, Woolloongabba

6150

RECRUITING

Fiona Stanley Hospital, Murdoch

Unknown

NOT_YET_RECRUITING

Bankstown-Lidcombe Hospital, Bankstown

NOT_YET_RECRUITING

John Hunter Hospital, Newcastle

NOT_YET_RECRUITING

Liverpool Hospital, Sydney

NOT_YET_RECRUITING

Gold Coast Hospital, Gold Coast

RECRUITING

Royal Adelaide Hospital, Adelaide

RECRUITING

Alfred Health, Melbourne

NOT_YET_RECRUITING

Austin Hospital, Melbourne

RECRUITING

Box Hill Hospital, Melbourne

NOT_YET_RECRUITING

Monash Health, Melbourne

RECRUITING

Royal Melbourne Hospital, Melbourne

NOT_YET_RECRUITING

Western Health, Melbourne

All Listed Sponsors
lead

University of Melbourne

OTHER