A Study of SAR444245 Combined With Other Anticancer Therapies for the Treatment of Participants With Gastrointestinal Cancer (Master Protocol) (Pegathor Gastrointestinal 203)

PHASE2CompletedINTERVENTIONAL
Enrollment

138

Participants

Timeline

Start Date

December 9, 2021

Primary Completion Date

July 26, 2023

Study Completion Date

September 9, 2024

Conditions
Oesophageal Squamous Cell CarcinomaGastric CancerHepatocellular CarcinomaColorectal CancerOesophageal Adenocarcinoma
Interventions
DRUG

THOR-707

Solution for infusion: intravenous infusion

DRUG

Pembrolizumab

Solution for infusion: intravenous infusion

DRUG

Cetuximab

Solution for infusion: intravenous infusion

Trial Locations (29)

2650

Investigational Site Number : 0560003, Edegem

3000

Investigational Site Number : 0560001, Leuven

20089

Investigational Site Number : 3800001, Rozzano

20132

Investigational Site Number : 3800003, Milan

20133

Investigational Site Number : 3800002, Milan

28007

Investigational Site Number : 7240003, Madrid / Madrid

28027

Investigational Site Number : 7240101, Madrid

28050

Investigational Site Number : 7240004, Madrid / Madrid

29200

Investigational Site Number : 2500006, Brest

31008

Investigational Site Number : 7240001, Pamplona

32804

AdventHealth Orlando Site Number : 8400005, Orlando

33075

Investigational Site Number : 2500004, Bordeaux

39008

Investigational Site Number : 7240005, Santander

75015

Investigational Site Number : 2500002, Paris

86021

Investigational Site Number : 2500005, Poitiers

91010

City of Hope Site Number : 8400007, Duarte

94800

Investigational Site Number : 2500001, Villejuif

98115

Seattle Cancer Care Alliance Site Number : 8400009, Seattle

430022

Investigational Site Number : 1560002, Wuhan

8420383

Investigational Site Number : 1520001, Santiago

BE-1200

Investigational Site Number : 0560002, Brussels

1081 HV

Investigational Site Number : 5280001, Amsterdam

3015 GD

Investigational Site Number : 5280003, Rotterdam

03080

Investigational Site Number : 4100002, Seoul

03722

Investigational Site Number : 4100004, Seoul

05505

Investigational Site Number : 4100001, Seoul

06351

Investigational Site Number : 4100003, Seoul

08035

Investigational Site Number : 7240002, Barcelona

08036

Investigational Site Number : 7240006, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Sanofi

INDUSTRY