Safety, Feasibility, and Efficacy of Non-invasive Vagus Nerve Stimulation (nVNS) in the Treatment of Aneurysmal Subarachnoid Hemorrhage

NARecruitingINTERVENTIONAL
Enrollment

25

Participants

Timeline

Start Date

October 4, 2022

Primary Completion Date

December 31, 2025

Study Completion Date

April 30, 2026

Conditions
Subarachnoid Hemorrhage, Aneurysmal
Interventions
DEVICE

gammaCore

Participants will receive two 2-minute non-invasive stimulations to the cervical branch of the vagus nerve (nVNS) three times daily with gammaCore, an FDA cleared device for the acute treatment and prevention of migraine and cluster headache. Intervention will begin within 72 hours post-rupture and end at 10 days post-rupture or discharge, whichever occurs first. The dosing regimen is supported by preclinical models and clinical data.

Trial Locations (1)

02114

RECRUITING

Massachusetts General Hospital, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

ElectroCore INC

INDUSTRY

lead

Massachusetts General Hospital

OTHER

NCT05103566 - Safety, Feasibility, and Efficacy of Non-invasive Vagus Nerve Stimulation (nVNS) in the Treatment of Aneurysmal Subarachnoid Hemorrhage | Biotech Hunter | Biotech Hunter