Zilebesiran as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication (KARDIA-2)

PHASE2CompletedINTERVENTIONAL
Enrollment

663

Participants

Timeline

Start Date

November 5, 2021

Primary Completion Date

December 11, 2023

Study Completion Date

September 13, 2024

Conditions
Hypertension
Interventions
DRUG

Indapamide

Indapamide administered orally

DRUG

Amlodipine

Amlodipine administered orally

DRUG

Olmesartan

Olmesartan administered orally

DRUG

Placebo

Placebo administered by SC injection

DRUG

Zilebesiran

Zilebesiran administered by SC injection

Trial Locations (110)

10036

Clinical Trial Site, New York

20011

Clinical Trial Site, Washington D.C.

22015

Clinical Trial Site, Burke

27157

Clinical Trial site, Winston-Salem

27403

Clinical Trial Site, Greensboro

27410

Clinical Trial Site, Greensboro

28112

Clinical Trial Site, Monroe

29566

Clinical Trial Site, Little River

30101

Clinical Trial Site, Acworth

30114

Clinical Trial Site, Canton

31406

Clinical Trial Site, Savannah

31904

Clinical Trial Site, Columbus

32162

Clinical Trial Site, Orlando

32256

Clinical Trial Site, Jacksonville

32789

Clinical Trial Site, Winter Park

32801

Clinical Trial Site, Orlando

33021

Clinical Trial Site, Hollywood

33024

Clinical Trial Site, Hollywood

33027

Clinical Trial Site, Pembroke Pines

33032

Clinical Trial Site, Miami

33073

Clinical Trial Site, Coconut Creek

33125

Clinical Trial Site, Miami

33134

Clinical Trial Site, Coral Gables

33135

Clinical Trial Site, Miami

33144

Clinical Trial Site, Miami

33176

Clinical Trial Site, Miami

33603

Clinical Trial Site, Tampa

33756

Clinical Trial Site, Clearwater

33880

Clinical Trial Site, Winter Haven

34105

Clinical Trial Site, Naples

34452

Clinical Trial Site, Inverness

38119

Clinical Trial Site, Memphis

39209

Clinical Trial Site, Jackson

40202

Clinical Trial Site, Louisville

48195

Clinical Trial Site, Southgate

53142

Clinical Trial Site, Kenosha

63042

Clinical Trial Site, Hazelwood

65109

Clinical Trial Site, Jefferson City

70769

Clinical Trial Site, New Orleans

73072

Clinical Trial Site, Norman

75019

Clinical Trial Site, Coppell

75024

Clinical Trial Site, Plano

75092

Clinical Trial Site, Sherman

75251

Clinical Trial Site, Dallas

76401

Clinical Trial Site, Stephenville

76708

Clinical Trial Site, Waco

77074

Clinical Trial Site, Houston

77081

Clinical Trial Site, Houston

77372

Clinical Trial Site, Splendora

77375

Clinical Trial Site, Tomball

77566

Clinical Trial Site, Lake Jackson

79109

Clinical Trial Site, Amarillo

85213

Clinical Trial Site, Mesa

85281

Clinical Trial Site, Tempe

85282

Clinical Trial Site, Tempe

90057

Clinical Trial Site, Los Angeles

90201

Clinical Trial Site, Bell Gardens

90211

Clinical Trials Site, Beverly Hills

90280

Clinical Trial Site, South Gate

90805

Clinical Trial Site, Long Beach

91304

Clinical Trial Site, Canoga Park

91345

Clinical Trial Site, Mission Hills

91355

Clinical Trial Site, Santa Clarita

91402

Clinical Trial Site, Panorama City

91606

Clinical Trial Site, Hollywood

91786

Clinical Trial Site, Upland

92008

Clinical Trial Site, Carlsbad

92024

Clinical Trial Site, Encinitas

92056

Clinical Trial Site, Oceanside

92103

Clinical Trial Site, San Diego

92614

Clinical Trial Site, Irvine

92647

Clinical Trial Site, Huntington Beach

92780

Clinical Trial Site, Tustin

92844

Clinical Trial Site, Garden Grove

Unknown

Clinical Trial Site, Brampton

Clinical Trial Site, Concord

Clinical Trial Site, Toronto

Clinical Trial Site, Winnipeg

Clinical Trial Site, Chicoutimi

Clinical Trial Site, Lévis

Clinical Trial Site, Pointe-Claire

Clinical Trial Site, Québec

Clinical Trial Site, Sherbrooke

Clinical Trial Site, Trois-Rivières

Clinical Trial Site, Québec

Clinical Trial Site, Tartu

Clinical Trial Site, Frankfurt

Clinical Trial Site, Riga

Clinical Trial Site, Kaunas

Clinical Trial Site, Vilnius

Clinical Trial Site, Częstochowa

Clinical Trial Site, Gdansk

Clinical Trial Site, Katowice

Clinical Trial Site, Staszów

Clinical Trial Site, Warsaw

Clinical Trial Site, Wroclaw

Clinical Trial Site, Carshalton

Clinical Trial Site, Edinburgh

Clinical Trial Site, Fowey

Clinical Trial Site, Glasgow

Clinical Trial Site, Lancashire Preston

Clinical Trial Site, Liskeard

Clinical Trial Site, London

Clinical Trial Site, Manchester

Clinical Trial Site, Newquay

Clinical Trial Site, Plymouth

Clinical Trial Site, Sheffield

Clinical Trial Site, Torpoint

N5W 6A2

Clinical Trial Site, London

ML4 3NJ

Clinical Trial Site, Bellshill

Sponsors
All Listed Sponsors
lead

Alnylam Pharmaceuticals

INDUSTRY