Enhancing Prefrontal Oscillations and Working Memory in Early-course Schizophrenia

NARecruitingINTERVENTIONAL
Enrollment

75

Participants

Timeline

Start Date

November 5, 2021

Primary Completion Date

August 31, 2026

Study Completion Date

August 31, 2026

Conditions
Schizophrenia
Interventions
DEVICE

active intermittent Theta Burst Stimulation (iTBS)

iTBS is a brief stimulation of a part of the brain with a magnetic field that passes through the scalp and skull safely. It is FDA-approved as a treatment for psychological conditions including depression; however, this device is not approved for the treatment of adults with patients with schizophrenia. This research study is using iTBS off label in SCZ patients to examine research questions.

DEVICE

sham intermittent Theta Burst Stimulation (iTBS)

"Sham TBS over the left DLPFC will be performed using a Cool-B65 A/P TMS coil, designed to support blinded clinical trials. Specifically, when the coil is placed in the P position (i.e. the placebo position), only a very small amount of current is induced in tissue, thus preventing the activation of cortical neurons."

Trial Locations (1)

15213

RECRUITING

University of Pittsburgh, Pittsburgh

All Listed Sponsors
collaborator

National Institute of Mental Health (NIMH)

NIH

lead

Fabio Ferrarelli

OTHER