STK-012 Monotherapy and in Combination Therapy in Patients With Solid Tumors

PHASE1RecruitingINTERVENTIONAL
Enrollment

202

Participants

Timeline

Start Date

January 25, 2022

Primary Completion Date

October 31, 2027

Study Completion Date

October 31, 2027

Conditions
Advanced Solid TumorNon Small Cell Lung CancerHead and Neck Squamous Cell CarcinomaMalignant MelanomaRenal Cell CarcinomaCervical CancerMicrosatellite Instability HighGastric CancerGastroEsophageal CancerUrothelial CarcinomaMismatch Repair DeficiencyUntreated Advanced NSCLC1st Line NSCLC
Interventions
DRUG

STK-012

pegylated alpha/beta-biased engineered interleukin-2

DRUG

pembrolizumab

anti-PD-1 humanized monoclonal antibody

DRUG

pemetrexed

antifolate chemotherapy

DRUG

carboplatin

platinum chemotherapy

Trial Locations (27)

10016

RECRUITING

NYU Langone Health, New York

10032

RECRUITING

Columbia University Irving Medical Center, New York

10065

RECRUITING

Memorial Sloan-Kettering Cancer Center, New York

11042

RECRUITING

Northwell Health, Lake Success

15232

ACTIVE_NOT_RECRUITING

UPMC Hillman Cancer Center, Pittsburgh

20057

RECRUITING

Georgetown University, Washington D.C.

22031

RECRUITING

NEXT Virginia, Fairfax

27710

RECRUITING

Duke Cancer Center, Durham

30322

RECRUITING

Winship Cancer Institute, Emory University, Atlanta

37203

RECRUITING

Sarah Cannon Research Institute - Nashville, Nashville

38120

RECRUITING

Baptist Memorial Hospital Cancer Center, Memphis

43210

RECRUITING

The James Cancer Hospital and Solove Research Institute, Columbus

55101

RECRUITING

HealthPartners Cancer Center at Regions Hospital, Saint Paul

77303

RECRUITING

Oncology Consultants, Houston

77380

RECRUITING

Renovatio Clinical, The Woodlands

79915

RECRUITING

Renovatio Clinical, El Paso

85721

RECRUITING

University of Arizona Cancer Center, Tucson

90211

RECRUITING

Beverly Hills Cancer Center, Beverly Hills

90404

RECRUITING

UCLA Hematology/Oncology - Santa Monica, Santa Monica

92663

RECRUITING

Hoag Memorial Hospital Presbyterian, Newport Beach

92835

RECRUITING

Providence Medical Foundation, Fullerton

98405

RECRUITING

Northwest Medical Specialties, Tacoma

92093-0698

ACTIVE_NOT_RECRUITING

UC San Diego Moores Cancer Center, La Jolla

06510

RECRUITING

Yale New Haven Hospital, Yale Cancer Center, New Haven

02114

RECRUITING

Massachusetts General Hospital, Boston

02215

RECRUITING

Beth Israel Deaconess Medical Center, Boston

RECRUITING

Dana-Farber Cancer Institute, Boston

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Synthekine

INDUSTRY

NCT05098132 - STK-012 Monotherapy and in Combination Therapy in Patients With Solid Tumors | Biotech Hunter | Biotech Hunter