The Anaesthetic Ketamine as Treatment for Patients With Severe Acute Brain Injury

S-ketamines is an NMDA-receptor antagonist with sedative and analgesic properties. It will in the present trial be given in sedative doses (2-3 mg/kg/hour) in case of clustered SDs following a dosing algorithm according to SD occurrence.

Isotonic saline has the same appearance as S-ketamine with both being clear liquids with no bubbles or other distinguishing features.