EMANATE: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

400

Participants

Timeline

Start Date

December 10, 2021

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
ObesityGenetic Obesity
Interventions
DRUG

Setmelanotide

Subcutaneous Injection

DRUG

Placebo

Subcutaneous Injection

Trial Locations (56)

10029

Metropolitan Hospital Center, New York

Mount Sinai Hospital, New York

10032

Columbia University, New York

10117

Charite - Universitatsmedizin Berlin, Berlin

10306

Ten's Medical Center - Pediatric Endocrinology Clinic, Staten Island

14260

University of Buffalo, Buffalo

15213

UPMC Montefiore, Pittsburgh

17822

Geisinger Clinic, Danville

19104

Children's Hospital of Philadelphia, Philadelphia

26504

University of Patras School of Medicine, Rio

26506

West Virginia University, Morgantown

28040

Hospital Fundación Jimenez Díaz, Madrid

29010

Hospital Universitario Virgen de la Victoria de Málaga, Málaga

30024

InQuest Medical Research, Suwanee

32701

Advent Health, Altamonte Springs

33604

Centre Hospitalier Universitaire (CHU) de Bordeaux, Pessac

37232

Vanderbilt University School of Medicine, Nashville

45229

Cincinnati Children's Hospital Medical Center, Cincinnati

46014

Hospital General de Valencia, Valencia

48105

University of Michigan, Ann Arbor

49372

Hasharon Hospital, Petah Tikva

52621

Chaim Sheba MC, Safra Children's Hospital, Ramat Gan

54449

Marshfield Clinic Research Foundation, a Division of Marshfield Clinic, Inc, Marshfield

55902

Mayo Clinic, Rochester

60596

Endokrinologikum Frankfurt, Frankfurt

63017

St. Luke's Hospital, Chesterfield

63130

Washington University in St. Louis, St Louis

69677

GH Est Hopital Femme Mere Enfant, Lyon

75093

Endocrine Associates of Dallas and Plano, Plano

75651

Hu Pitie Salpetriere Aphp, Paris

75771

Hopital Armand Trousseau, Paris

77030

Texas Children's Hospital, Houston

77084

Biopharma Informatic, Houston

78503

Rio Grande Valley Endocrine Center, McAllen

79106

Texas Tech, Amarillo

80045

Children's Hospital Colorado, Aurora

85016

Phoenix Children's Hospital, Phoenix

85258

HonorHealth Bariatric Center, Scottsdale

89075

Universitaetsklinikum Ulm, Ulm

90027

Children's Hospital Los Angeles, Los Angeles

97239

Oregon Health & Science University, Portland

97400

Hôpital Félix Guyon Bellepierre, Saint-Denis

98405

MultiCare Health System Institute for Research and Innovation, Tacoma

06519

Yale Center for Clinical Investigation, New Haven

01655

UMASS Memorial Medical Center, Worcester

48126-2619

Metro Detroit Endocrinology Center, Dearborn

T6G 2E1

University of Alberta - Alberta Diabetes Institute (ADI), Edmonton

04103

Universitaetsklinikum Leipzig, Leipzig

3015 GD

Erasmus Medisch Centrum, Rotterdam

00925-253

University of Puerto Rico, San Juan

08950

Hospital Sant Joan de Deu, Barcelona, Barcelona

BS2 8AE

Bristol Royal Hospital for Children, Bristol

CB2 0QQ

University of Cambridge, Cambridge

L9 7AL

Aintree University Hospital, Liverpool

NW1 2PG

London Medical - The London Diabetes Centre, London

WC1E6JF

University College London Hospitals NHS Foundation Trust, London

All Listed Sponsors
lead

Rhythm Pharmaceuticals, Inc.

INDUSTRY