Efficacy and Safety of Selective JAK 1 Inhibitor Filgotinib in Active Rheumatoid Arthritis Patients With Inadequate Response to Methotrexate

PHASE3UnknownINTERVENTIONAL
Enrollment

400

Participants

Timeline

Start Date

March 3, 2021

Primary Completion Date

February 28, 2023

Study Completion Date

December 31, 2023

Conditions
Rheumatoid ArthritisJAK InhibitorIL-6 InhibitorMusculoskeletal UltrasoundBiomarker
Interventions
DRUG

filgotinib 200mg/day

Patients will be randomized in a 1:1 ratio to the administration of filgotinib 200mg/day or subcutaneous tocilizumab 162mg/biweekly switched from MTX ± other csDMARDs throughout the study period.

DRUG

subcutaneous tocilizumab 162mg/biweekly

Patients will be randomized in a 1:1 ratio to the administration of filgotinib 200mg/day or subcutaneous tocilizumab 162mg/biweekly switched from MTX ± other csDMARDs throughout the study period.

Trial Locations (1)

852-8501

RECRUITING

Nagasaki University Hospital, Nagasaki

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Gilead Sciences

INDUSTRY

lead

Atsushi Kawakami

OTHER