Pediatric GVHD Low Risk Steroid Taper Trial

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

October 20, 2022

Primary Completion Date

March 27, 2025

Study Completion Date

March 31, 2026

Conditions
Acute Graft vs Host DiseaseAllogeneic Bone Marrow TransplantationAdverse Effects
Interventions
DRUG

Prednisone

Prednisone starting dose of 0.5 mg/kg; for patients who respond clinically and continue to have low biomarkers will be tapered rapidly; those that are not clinically responding or whose biomarkers increase will be treated per their treating physicians plan or by standard of care

Trial Locations (11)

10029

Icahn School of Medicine at Mount Sinai, New York

10065

Memorial Sloan Kettering Cancer Center, New York

19104

Children's Hospital of Philadelphia, Philadelphia

20010

Children's National Hospital, Washington D.C.

30322

Children's Healthcare of Atlanta, Atlanta

37235

Vanderbilt University Medical Center, Nashville

53226

Medical College of Wisconsin / Children's Wisconsin, Milwaukee

77030

Texas Children's Hospital, Baylor College of Medicine, Houston

90027

Children's Hospital of Los Angeles, Los Angeles

02115

Boston Children's Hospital Dana Farber Cancer Institute, Boston

M5S

The Hospital for Sick Children, Toronto

All Listed Sponsors
lead

John Levine

OTHER