An Open-Label Extension Study to Evaluate Safety & Tolerability of QR-421a in Subjects With Retinitis Pigmentosa

PHASE2TerminatedINTERVENTIONAL
Enrollment

21

Participants

Timeline

Start Date

September 16, 2021

Primary Completion Date

October 18, 2022

Study Completion Date

October 18, 2022

Conditions
Retinitis PigmentosaUsher Syndrome Type 2
Interventions
DRUG

RNA antisense oligonucleotide for intravitreal injection

"QR-421a will be first administered to the fellow eye (as defined in the preceding study), and will be repeated every 6 months.~Treatment of the study eye (as defined in the preceding study) can commence 3 months (9 months for subjects from study PQ-421a-001) after the treatment of the fellow eye has been initiated and will be repeated every 6 months as well.~Continued subject treatment in this study will be pursued provided that the benefit-risk balance is positive for the individual subject."

Trial Locations (7)

34295

Hôpital Gui de Chauliac - CHRU de Montpellier - Maladies Sensorielles Génétique, Montpellier

48105

University of Michigan, Kellogg Eye Center, Ann Arbor

75012

Centre de maladies rares CHNO des Quinze Vingts, Paris

75231

Retina Foundation of the Southwest, Dallas

97239

Casey Eye Institute, Oregon Health & Science University, Portland

02114

Center for Clinical Research Operations, Massachusetts Eye and Ear, Boston

H4A 3J1

Centre for Innovative Medicine, Department of Paediatric Surgery, Montreal Children's Hospital at the McGill University Health Centre, Montreal

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Sepul Bio

INDUSTRY

lead

Laboratoires Thea

INDUSTRY