SNIFF - Combo INI+EMPA Trial

PHASE2CompletedINTERVENTIONAL
Enrollment

47

Participants

Timeline

Start Date

September 14, 2021

Primary Completion Date

September 17, 2024

Study Completion Date

September 17, 2024

Conditions
Mild Cognitive ImpairmentCognitive ImpairmentAlzheimer Disease
Interventions
DRUG

Insulin (Humulin® R U-100)

Participants will administer 40 IU of Humulin® U-100 insulin four times per day with an intranasal delivery device.

DRUG

Empagliflozin 10 MG

Participants will be assigned to receive Empagliflozin 10 mg capsules to be taken by mouth once daily.

DEVICE

Aptar Pharma CPS Intranasal Delivery Device

Participants will be assigned to receive Humulin® insulin or placebo administered through the Aptar Pharma CPS intranasal delivery device.

DRUG

Placebo (Insulin Diluent)

Participants will administer placebo (insulin diluent) four times per day with an intranasal delivery device.

DRUG

Placebo (Capsules)

Participants will be assigned to receive placebo capsules (Empagliflozin 10 mg) to be taken by mouth once daily.

Trial Locations (1)

27157

Wake Forest University Health Sciences / Wake Forest School of Medicine, Winston-Salem

All Listed Sponsors
lead

Wake Forest University Health Sciences

OTHER

NCT05081219 - SNIFF - Combo INI+EMPA Trial | Biotech Hunter | Biotech Hunter