NCT05075980 - Intensity Modulated Proton or X-Ray Therapy After Surgery for Treatment of Head and Neck Cancer, the HEADLIGHT Study | Biotech Hunter

Enrollment

174

Participants

Timeline

Start Date

February 16, 2022

Primary Completion Date

November 15, 2027

Study Completion Date

November 15, 2035

Conditions

Head and Neck CarcinomaHead and Neck Carcinoma of Unknown PrimaryHypopharyngeal CarcinomaLaryngeal CarcinomaMetastatic Malignant Neoplasm in the Lymph NodesNasal Cavity CarcinomaOral Cavity CarcinomaOropharyngeal CarcinomaParanasal Sinus CarcinomaSalivary Gland CarcinomaCutaneous Squamous Cell Carcinoma of the Head and NeckLocally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck

Interventions

DRUG

Cisplatin

Given IV

PROCEDURE

Intensity-Modulated Proton Therapy

Undergo IMPT

OTHER

Quality-of-Life Assessment

Ancillary studies

OTHER

Questionnaire Administration

Ancillary studies

PROCEDURE

Computed Tomography

Undergo CT or PET/CT

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI or PET/MRI

PROCEDURE

Positron Emission Tomography

Undergo PET/CT or PET/MRI

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

RADIATION

Intensity-Modulated Radiation Therapy

Undergo IMRT

Trial Locations (9)

32224

RECRUITING

Mayo Clinic in Florida, Jacksonville

54601

RECRUITING

Mayo Clinic Health System - Franciscan Healthcare, La Crosse

54701

RECRUITING

Mayo Clinic Health System - Eau Claire, Eau Claire

55057

RECRUITING

Mayo Clinic Radiation Therapy - Northfield, Northfield

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

56001

RECRUITING

Mayo Clinic Health System - Mankato, Mankato

56007

RECRUITING

Mayo Clinic Health System in Albert Lea, Albert Lea

85054

RECRUITING

Mayo Clinic Hospital in Arizona, Phoenix

85259

RECRUITING

Mayo Clinic in Arizona, Scottsdale