Relapsed/Refractory Large B-cell Lymphoma With NT-I7 Post-CD19 CAR T-cell Therapy

PHASE1CompletedINTERVENTIONAL
Enrollment

17

Participants

Timeline

Start Date

August 6, 2021

Primary Completion Date

December 18, 2024

Study Completion Date

March 12, 2025

Conditions
Refractory Diffuse Large B-cell LymphomaRefractory Diffuse Large B-Cell Lymphoma, Not Otherwise SpecifiedRecurrent Diffuse Large B-Cell LymphomaRefractory High Grade B-Cell LymphomaRefractory Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma
Interventions
DRUG

Efineptakin alfa

NT-I7 is administered via an intramuscular injection after CAR-T infusion on Day 21.

DRUG

Tisagenlecleucel

Administered as standard of care as described in the package insert on Day 0.

DRUG

Axicabtagene ciloleucel

Administered as standard of care as described in the package insert on Day 0.

DRUG

Lisocabtagene Maraleucel

Administered as standard of care as described in the package insert on Day 0.

Trial Locations (4)

27710

Duke Cancer Institute, Durham

48201

Barbara Ann Karmanos Cancer Hospital dba Karmanos Cancer Center, Detroit

63110

Washington University in St. Louis, St Louis

91010

City of Hope, Duarte

Sponsors

Lead Sponsor

All Listed Sponsors
lead

NeoImmuneTech

INDUSTRY

NCT05075603 - Relapsed/Refractory Large B-cell Lymphoma With NT-I7 Post-CD19 CAR T-cell Therapy | Biotech Hunter | Biotech Hunter