To Evaluate the Efficacy and Safety of Nemolizumab for 12 Weeks in Participants With Chronic Kidney Disease With Associated Moderate to Severe Pruritus

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

258

Participants

Timeline

Start Date

December 29, 2021

Primary Completion Date

January 4, 2024

Study Completion Date

January 4, 2024

Conditions
Chronic Kidney Disease Associated Moderate to Severe Pruritus
Interventions
DRUG

Nemolizumab

Participants received a loading dose of 60 mg nemolizumab at Baseline followed by 2 Subcutaneous (SC) injections for a total dose of 30 mg nemolizumab once every 4 weeks i.e. at Week 4 and Week 8.

DRUG

Nemolizumab

Participants received 2 SC injections of 30 mg nemolizumab once every 4 weeks i.e. at Week 4 and Week 8.

DRUG

Placebo

Participants received 2 SC injections of 30 mg placebo-matched to nemolizumab once every 4 weeks i.e. at Week 4 and Week 8.

Trial Locations (64)

1076

Galderma Investigational Site 6301, Budapest

3526

Galderma Investigational Site 6305, Miskolc

6000

Galderma Investigational Site 6304, Kecskemét

6600

Galderma Investigational Site 6310, Szentes

9700

Galderma Investigational Site 6298, Szombathely

10461

Galderma Investigational Site 9995, The Bronx

11021

Galderma Investigational Site 9998, Great Neck

11365

Galderma Investigational Site 7038, Fresh Meadows

14004

Galderma Investigational Site 6292, Córdoba

23502

Galderma Investigational Site 9968, Norfolk

27103

Galderma Investigational Site 7007, Winston-Salem

28040

Galderma Investigational Site 5171, Madrid

28046

Galderma Investigational Site 6190, Madrid

28108

Galderma Investigational Site 6309, Alcobendas

29306

Galderma Investigational Site 9999, Spartanburg

31904

Galderma Investigational Site 7027, Columbus

32771

Galderma Investigational Site 7032, Sanford

33021

Galderma Investigational Site 7026, Hollywood

33125

Galderma Investigational Site 9965, Miami

33134

Galderma Investigational Site 7037, Coral Gables

33155

Galderma Investigational Site7016, Miami

33421

Galderma Investigational Site 9970, Boca Raton

33603

Galderma Investigational Site 7004, Tampa

Galderma Investigational Site 7025, Tampa

37404

Galderma Investigational Site 9967, Chattanooga

41009

Galderma Investigational Site 6295, Seville

46017

Galderma Investigational Site 6311, Valencia

46940

Galderma Investigational Site 6278, Manises

48066

Galderma Investigational Site 9963, Roseville

53226

Galderma Investigational Site 9969, Wauwatosa

55404

Galderma Investigational Site 9982, Minneapolis

55435

Galderma Investigational Site 7020, Edina

64111

Galderma Investigational Site 7035, Kansas City

66210

Galderma Investigational Site 9983, Overland Park

67214

Galderma Investigational Site 9972, Wichita

75069

Galderma Investigational Site 7022, McKinney

75231

Galderma Investigational Site 7040, Dallas

75402

Galderma Investigational Site 9977, Greenville

76015

Galderma Investigational Site 7039, Arlington

77054

Galderma Investigational Site 7011, Houston

77384

Galderma Investigational Site 7019, The Woodlands

78258

Galderma Investigational Site 7010, San Antonio

79925

Galderma Investigational Site 9966, El Paso

80230

Galderma Investigational Site 9971, Denver

89128

Galderma Investigational Site 9962, Las Vegas

90048

Galderma Investigational Site 9996, Los Angeles

90262

Galderma Investigational Site 9978, Lynwood

90603

Galderma Investigational Site 7003, Whittier

90623

Galderma Investigational Site 7015, La Palma

91205

Galderma Investigational Site 9991, Glendale

91206

Galderma Investigational Site 7018, Glendale

91356

Galderma Investigational Site 9973, Tarzana

92392

Galderma Investigational Site 7028, Victorville

92505

Galderma Investigational Site 7017, Riverside

93309

Galderma Investigational Site 9989, Bakersfield

97471

Galderma Investigational Site 9992, Roseburg

92394-1868

Galderma Investigational Site 9964, Victorville

06002

Galderma Investigational Site 9988, Bloomfield

06762

Galderma Investigational Site 9980, Middlebury

87-300

Galderma Investigational Site 6294, Brodnica

90-153

Galderma Investigational Site 6296, Lodz

32-300

Galderma Investigational Site 6293, Olkusz

50-556

Galderma Investigational Site 6297, Wroclaw

08097

Galderma Investigational Site 5580, L'Hospitalet de Llobregat

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Galderma R&D

INDUSTRY