Comparison of Type 2 Diabetes Pharmacotherapy Regimens

RecruitingOBSERVATIONAL
Enrollment

270,000

Participants

Timeline

Start Date

July 1, 2021

Primary Completion Date

December 31, 2024

Study Completion Date

August 31, 2025

Conditions
Type 2 Diabetes MellitusCardiovascular Diseases
Interventions
DRUG

SU

Exposure to the class of drugs known as Sulfonylureas (SU)

DRUG

DPP4

Exposure to the class of drugs known as Dipeptidyl peptidase-4 inhibitors (DPP4)

DRUG

SGLT2i

Exposure to the class of drugs known as Sodium-glucose cotransporter-2 inhibitors (SGLT2i)

DRUG

GLP-1RA

Exposure to the class of drugs known as Glucagon-like peptide-1 receptor agonists (GLP-1RA)

DRUG

SGLT2i or GLP-1RA

Exposure to either SGLT2i or GLP-1RA

DRUG

Linagliptin (DPP4)

Exposure to agent Linagliptin (DPP4)

DRUG

Exenatide (GLP-1RA)

Exposure to agent Exenatide (GLP1-RA)

DRUG

Liraglutide (GLP-1RA)

Exposure to agent Liraglutide (GLP-1RA)

DRUG

Empagliflozin (SGLT2i)

Exposure to agent Empagliflozin (SGLT2i)

DRUG

Glimepiride (SU)

Exposure to agent Glimepiride (SU)

DRUG

Glipizide (SU)

Exposure to Glimepiride (SU)

DRUG

Glimepiride (SU) or Glipizide (SU)

Exposure to agent Glimepiride (SU) or Glipizide (SU)

DRUG

SU or DPP4 (excluding saxagliptin and alogliptin)

Exposure to either SU or DPP4 excluding Saxagliptin and Alogliptin

DRUG

Exenatide (GLP-1RA) or Liraglutide (GLP-1RA)

Exposure to either Exenatide (GLP-1RA) or Liraglutide (GLP-1RA)

Trial Locations (6)

17821

RECRUITING

Geisinger, Danville

48202

RECRUITING

Henry Ford Health System, Detroit

55425

RECRUITING

HealthPartners Institute, Bloomington

91101

RECRUITING

Kaiser Permanente Southern California, Pasadena

94612

RECRUITING

Romain S. Neugebauer, Oakland

96817

RECRUITING

Kaiser Permanente Hawaii, Honolulu

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Geisinger Clinic

OTHER

collaborator

Henry Ford Health System

OTHER

collaborator

HealthPartners Institute

OTHER

collaborator

Patient-Centered Outcomes Research Institute

OTHER

lead

Kaiser Permanente

OTHER