A Study to Assess the Long-Term Safety and Efficacy of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Patients With Hereditary Transthyretin-Mediated Amyloid Polyneuropathy

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

151

Participants

Timeline

Start Date

January 4, 2022

Primary Completion Date

August 31, 2029

Study Completion Date

August 31, 2029

Conditions
Hereditary Transthyretin-Mediated Amyloid Polyneuropathy
Interventions
DRUG

Eplontersen

Eplontersen will be administered by SC injection.

Trial Locations (33)

100

National Taiwan University Hospital, Taipei

333

Chang Gung Memorial Hospital, Taoyuan District

1888

Hospital El Cruce, San Juan Bautista

2371

The Cyprus Institute of Neurology and Genetics, Égkomi

6150

Perron Institute for Neurological and Translational Science, Murdoch

10032

The Neurological Institute of New York, New York

11217

Taipei Veterans General Hospital, Taipei

13385

Hôpital de la Timone, Marseille

20133

Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Fondazione Istituto Neurologico Carlo Besta, Milan

21287

Johns Hopkins University Neurology Research Office, Baltimore

27100

Fondazione IRCCS Policlinico San Matteo, Pavia

27514

University of North Carolina Hospitals - Neurology Clinic, Chapel Hill

28040

Hospital Clínico San Carlos, Madrid

31059

Centre Hospitalier Universitaire de Toulouse, Toulouse

34093

Istanbul Üniversitesi - Istanbul Tip Fakültesi, Istanbul

40447

China Medical University Hospital, Taichung

46202

Indiana University Health University Hospital, Indianapolis

85259

Mayo Clinic, Scottsdale

97239

Oregon Health and Science University, Portland

98195

University of Washington Medical Center, Seattle

02118

Boston University School of Medicine, Boston

C1199ABB

Hospital Italiano de Buenos Aires, Buenos Aires

C1428 AQK

Instituto Fleni, Buenos Aires

22281-100

Hospital Universitario Clementino Fraga Filho, Botafogo

13083-888

Universidade Estadual de Campinas, Campinas

81210-310

Instituto de Neurologia de Curitiba, Curitiba

14051-140

Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, São Paulo

V5Z 1M9

Vancouver General Hospital, Vancouver

M5G2C4

Toronto General Hospital, Toronto

1649-035

Centro Hospitalar Universitário Lisboa Norte - Hospital De Santa Maria, Lisbon

4099-001

Centro Hospitalar Universitário do Porto - Hospital Geral de Santo Antonio, Porto

07198

Hospital Son Llàtzer, Palma de Mallorca

901 85

Norrlands Universitetssjukhus, Umeå

Sponsors
All Listed Sponsors
lead

Ionis Pharmaceuticals, Inc.

INDUSTRY