A Controlled Human Vivax Malaria Infection Study Through Inoculation of Infected Erythrocytes

NARecruitingINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

May 23, 2022

Primary Completion Date

November 30, 2025

Study Completion Date

November 30, 2025

Conditions
Plasmodium Vivax Infection
Interventions
BIOLOGICAL

An inoculum of malaria parasitised red blood cells with whole dose blood-stage inoculum

An inoculum of malaria parasitised red blood cells reconstituted in 0.9% normal saline, to a total volume of 5 mL; challenge with whole dose blood-stage inoculum (neat)

BIOLOGICAL

An inoculum of malaria parasitised red blood cells with 1:5 dilution blood-stage inoculum

An inoculum of malaria parasitised red blood cells reconstituted in 0.9% normal saline, to a total volume of 5 mL; challenge with 1:5 dilution blood-stage inoculum

BIOLOGICAL

An inoculum of malaria parasitised red blood cells with 1:10 dilution blood-stage inoculum

An inoculum of malaria parasitised red blood cells reconstituted in 0.9% normal saline, to a total volume of 5 mL; challenge with 1:10 dilution blood-stage inoculum

BIOLOGICAL

An inoculum of malaria parasitised red blood cells with 1:20 dilution blood-stage inoculum

An inoculum of malaria parasitised red blood cells reconstituted in 0.9% normal saline, to a total volume of 5 mL; challenge with 1:20 dilution blood-stage inoculum

Trial Locations (1)

10400

RECRUITING

Faculty of Tropical Medicine, Bangkok

All Listed Sponsors
collaborator

Wellcome Trust

OTHER

lead

University of Oxford

OTHER