Drug-Drug Interaction Study of Evobrutinib and Transporter Substrates

PHASE1CompletedINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

October 4, 2021

Primary Completion Date

December 10, 2021

Study Completion Date

December 10, 2021

Conditions
Healthy
Interventions
DRUG

Evobrutinib

Participants will receive evobrutinib film-coated tablet, twice daily under fed conditions from Days 4 to 12 in Part 1 and from Days 2 to 8 in Part 2 of the study.

DRUG

Digoxin

Participants will receive digoxin tablet under fed conditions, once a day on Day 1 and Day 10 in Part 1.

DRUG

Metformin

Participants will receive metformin oral solution under fed conditions, once a day on Day 1 and Day 10 in Part 1.

DRUG

Rosuvastatin

Participants will receive rosuvastatin tablet under fed conditions, once a day on Day 1 and Day 10 in Part 1.

DRUG

Sumatriptan

Participants will receive sumatriptan tablet under fed conditions, once a day on Day 1 and Day 8 in Part 2.

Trial Locations (1)

89231

Nuvisan GmbH, Neu-Ulm

All Listed Sponsors
lead

Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

INDUSTRY

NCT05064488 - Drug-Drug Interaction Study of Evobrutinib and Transporter Substrates | Biotech Hunter | Biotech Hunter