A Study to Evaluate THR-687 Treatment for Diabetic Macular Oedema.

PHASE2TerminatedINTERVENTIONAL
Enrollment

16

Participants

Timeline

Start Date

August 27, 2021

Primary Completion Date

June 29, 2022

Study Completion Date

June 29, 2022

Conditions
Diabetes MellitusDiabetic RetinopathyDiabetic Macular Edema
Interventions
DRUG

THR-687 dose level 1

3 intravitreal injections of THR-687 dose level 1, 1 month apart

DRUG

THR-687 dose level 2

3 intravitreal injections of THR-687 dose level 2, 1 month apart

DRUG

THR-687 selected dose level

3 intravitreal injections of THR-687 selected dose level, 1 month apart, possibly followed by a 4th intravitreal injection with the same dose level of THR-687 at Month 3, or Month 4, or Month 5, if any of the PRN criteria are met.

DRUG

Aflibercept

3 intravitreal injections of aflibercept, 1 month apart, possibly followed by a 4th intravitreal injection with aflibercept at Month 3, or Month 4, or Month 5, if any of the PRN criteria are met.

Trial Locations (25)

6720

Szegedi Tudományegyetem, Szeged

7621

Ganglion Medical Center, Pécs

11314

Eye Clinic Dr Krista Turman, Tallinn

11412

Silmalaser OU, Tallinn

13088

Retina Vitreous Surgeons of Central New York, PC, Liverpool

18704

Eye Care Specialists, Kingston

21740

Cumberland Valley Retina Consultants, Hagerstown

37203

Tennessee Retina, PC, Nashville

60126

Retina Associates, Ltd, Elmhurst

60452

University Retina and macula Associates, PC, Oak Forest

74114

Tulsa Retina Consultants, Tulsa

76087

Strategic Clinical Research Group, Willow Park

76092

Retina Center of Texas, Southlake

77494

Retina Consultants of Texas, Katy

78240

Medical Center Ophthalmology Associates, San Antonio

78503

Valley Retina Institute, P.A., McAllen

78705

Austin Research Center of Retina, Austin

80909

Retina Consultants of Southern Colorado, P.C., Colorado Springs

89502

Sierra Eye Associates, Reno

91107

California Eye Specialists Medical Group, Inc., Pasadena

92647

Salehi Retina Institute Inc., Huntington Beach

95825

Retinal Consultants Medical Group, Sacramento

LV-1002

Pauls Stradins Clinical University Hospital, Riga

LV-1006

Riga East Clinical University Hospital, Riga

LT-08661

Vilnius University Hospital Santaros klinikos, Vilnius

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Oxurion

INDUSTRY