NCT05062005View on ClinicalTrials.gov

ICCRT vs. CRT for Locally Advanced Nasopharyngeal Carcinoma

PHASE3RecruitingINTERVENTIONAL
Enrollment

447

Participants

Timeline

Start Date

September 22, 2021

Primary Completion Date

August 31, 2027

Study Completion Date

August 31, 2027

Conditions
Locally Advanced Nasopharyngeal Carcinoma
Interventions
DRUG

Induction Chemotherapy

Induction regimens: TP (docetaxel 75 mg/m²; cisplatin 75 mg/m²) Q3w, TPF (docetaxel 60 mg/m²; cisplatin 60 mg/m²; 5-fluorouracil 600-750 mg/m² per day, continuous intravenous infusion d1-5) Q3w, or GP (gemcitabine: 1000 mg/m2 d1, d8; cisplatin 80 mg/m2) Q3w.

DRUG

Concurrent Chemotherapy

Cisplatin 100 mg/m², Q3w.

RADIATION

Definitive Radiotherapy

For all patients, the prescribed dose is 66-70 Gy (once a day, 5 times a week).

Trial Locations (1)

510080

RECRUITING

The First Affiliated Hospital of Sun Yat-sen University, Guangzhou

All Listed Sponsors
lead

First Affiliated Hospital, Sun Yat-Sen University

OTHER