Study of Belantamab Mafodotin in Combination With Kd for the Treatment of Relapsed Myeloma Patients, Refractory to Lenalidomide

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

December 20, 2021

Primary Completion Date

May 31, 2024

Study Completion Date

May 30, 2028

Conditions
Relapsed Multiple Myeloma
Interventions
DRUG

Belantamab mafodotin

"In phase 1:~* Dose level -1: Belantamab-Mafodotin 1.9 mg/kg day 1, Q8W~* Dose level 1,2,3: Belantamab-Mafodotin 2.5 mg/kg day 1, Q8W In phase 2: maximum tolerated dose (MTD) of the combination"

DRUG

Carfilzomib

"In phase 1:~* Dose level -1, 1: Carfilzomib 20/45 mg/m2 days 1, 8, and 15, Q4W.~* Dose level 2: Carfilzomib 20/56 mg/m2 on days 1, 8, and 15, Q4W~* Dose level 3: Carfilzomib 20/70 mg/m2 on days 1, 8, and 15, Q4W.~In phase 2: maximum tolerated dose (MTD) of the combination"

DRUG

Dexamethasone

Description: Dexamethasone 40 mg weekly (days 1, 8, 15 and 22) or 20 mg in patients \> 75 years old., Q4W

Trial Locations (15)

Unknown

RECRUITING

Hospital Germans Trias i Pujol (ICO BADALONA), Badalona

NOT_YET_RECRUITING

Hospital Clinic, Barcelona

RECRUITING

ICO Hospitalet, Bellvitge

NOT_YET_RECRUITING

H. Gregorio Marañón, Madrid

NOT_YET_RECRUITING

Hospital Universitario 12 de Octubre, Madrid

RECRUITING

H. Morales Meseguer, Murcia

RECRUITING

HUCA, Oviedo

RECRUITING

H. Son Llatzer, Palma de Mallorca

RECRUITING

Clínica Universidad de Navarra (CUN), Pamplona

RECRUITING

Hospital Universitario de Salamanca, Salamanca

NOT_YET_RECRUITING

H. Universitario de Canarias, Santa Cruz de Tenerife

NOT_YET_RECRUITING

H. Universitario Marqués de Valdecilla, Santander

RECRUITING

Complejo Hospitalario Santiago (CHUS), Santiago de Compostela

RECRUITING

Complejo Hospitalario Virgen del Rocío, Seville

RECRUITING

H.U. La Fe, Valencia

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Adknoma Health Research

INDUSTRY

lead

PETHEMA Foundation

OTHER