First-in-human Study of IO-108 as Single Agent and in Combination With a PD-1 Immune Check Point Inhibitor in Patients With Advanced Solid Tumors

PHASE1CompletedINTERVENTIONAL
Enrollment

91

Participants

Timeline

Start Date

September 30, 2021

Primary Completion Date

April 29, 2024

Study Completion Date

May 31, 2024

Conditions
Solid Tumor, Adult
Interventions
BIOLOGICAL

IO-108

IO-108 given as monotherapy

BIOLOGICAL

IO-108 + pembrolizumab combination therapy

IO-108 and fixed dose pembrolizumab combination therapy

BIOLOGICAL

IO-108 + cemiplimab combination therapy

IO-108 and fixed dose cemiplimab combination therapy

Trial Locations (24)

10016

NYU Langone Health (131), New York

15209

UPMC Hillman Cancer Center (105), Pittsburgh

21044

Maryland Oncology Hematology, PA (145) (USOR SITE), Columbia

22031

NEXT Oncology-Virginia (121), Fairfax

28078

Carolina BioOncology (102), Huntsville

32611

University of Florida (125), Gainesville

32746

Florida Cancer Specialists (134), Lake Mary

33021

Memorial Cancer Institute (146), Pembroke Pines

34232

Florida Cancer Specialists & Research Institute (103), Sarasota

34952

Hematology Oncology (136), Stuart

44718

Gabrail Cancer Center (128), Canton

45242

Oncology Hematology Care Clinical Trials, LLC (144) (USOR SITE), Cincinnati

46202

Indiana University Melvin and Bren Simon Comprehensive Cancer Center (123), Indianapolis

48201

Karmanos Cancer Institute (126), Detroit

59102

St. Vincent - Frontier Cancer Center (135), Billings

75246

Texas Oncology - Baylor Charles A. (143) (USOR SITE), Dallas

77030

MD Anderson Cancer Center (101), Houston

Oncology Consultants, P.A. (138), Houston

78705

Texas Oncology - Austin (142) (USOR SITE), Austin

80124

Rocky Mountain Cancer Centers, LLP (141) (USOR SITE), Lone Tree

85711

Arizona Oncology Associates, PC-HOPE (140) (USOR SITE), Tucson

90211

Beverly HIlls Cancer Center (129), Beverly Hills

97213

Providence Cancer Institute (104), Portland

98104

Swedish Cancer Institute (147), Seattle

Sponsors
All Listed Sponsors
collaborator

Regeneron Pharmaceuticals

INDUSTRY

lead

Immune-Onc Therapeutics

INDUSTRY

NCT05054348 - First-in-human Study of IO-108 as Single Agent and in Combination With a PD-1 Immune Check Point Inhibitor in Patients With Advanced Solid Tumors | Biotech Hunter | Biotech Hunter