PROSPECT - Profiling of Resistance Patterns & Oncogenic Signaling Pathways in Evaluation of Cancers of the Thorax and Therapeutic Target Identification

RecruitingOBSERVATIONAL
Enrollment

7,200

Participants

Timeline

Start Date

April 25, 2007

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Lung CancerCancer of Thorax
Interventions
OTHER

Group Specific Aim 1

600 cases: two normal and two tumor formalin-fixed tissue samples

OTHER

Group Specific Aim 2

600 cases: two normal and two tumor formalin-fixed tissue samples.

OTHER

Group Specific Aim 3

600 cases, including 150 patients who had received neoadjuvant therapy and 450 patients who had not. Two normal and two tumor formalin-fixed tissue samples

OTHER

Group Specific Aim 4

600 cases; including 150 patients who will receive neoadjuvant chemotherapy, 150 patients who received or will receive postoperative adjuvant chemotherapy, and 300 patients who did not receive or will not receive neoadjuvant or adjuvant chemotherapy. Two normal and two tumor formalin-fixed tissue samples

OTHER

Group Specific Aim 5

600 cases; two normal and two tumor formalin-fixed tissue samples

OTHER

Group Specific Aim 6

210 cases (of the 600 above), one normal and one tumor formalin-fixed histology sections obtained from formalin-fixed and paraffin- embedded tissue samples.

Trial Locations (1)

77030

RECRUITING

M D Anderson Caner Center, Houston

All Listed Sponsors
collaborator

United States Department of Defense

FED

collaborator

National Institutes of Health (NIH)

NIH

collaborator

National Cancer Institute (NCI)

NIH

lead

M.D. Anderson Cancer Center

OTHER