765
Participants
Start Date
January 4, 2022
Primary Completion Date
May 28, 2025
Study Completion Date
August 31, 2026
Continuous ketamine infusion
Continuous ketamine infusion (0.35 mg/kg after induction, followed by 0.25 mg/kg/hr until 2 hours after surgery) plus saline IV dose in post-anesthesia care unit
Ketamine + Saline
Saline dose and infusion intraoperatively, then single-dose IV ketamine (0.60 mg/kg) in post-anesthesia care unit plus 2 hours of saline administration after surgery
Placebo
Placebo, Saline dose and infusion intraoperatively, then saline IV dose in post-anesthesia care unit plus 2 hours of saline administration after surgery
NYU Langone Health (Tisch Hospital, Kimmel Pavilion), New York
New York Presbyterian Columbia University Irving Medical Center, New York
Memorial Sloan Kettering Cancer Center, New York
Montefiore Medical Center - Albert Einstein College of Medicine, The Bronx
University of Pittsburgh - Magee Women's Hospital, Pittsburgh
University of Alabama at Birmingham, Birmingham
Mayo Clinic, Rochester
Rush University Medical Center, Chicago
Washington University at St. Louis Medical Center, St Louis
University of Arkansas, Little Rock
University of Texas - Southwestern Medical Center, Dallas
University of Texas - MD Anderson Cancer Center, Houston
University of Washington Medical Center, Seattle
Brigham and Women's Hospital - Harvard University, Chestnut Hill
National Cancer Institute (NCI)
NIH
NYU Langone Health
OTHER