NCT05036226View on ClinicalTrials.gov

COAST Therapy in Advanced Solid Tumors and Prostate Cancer

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

76

Participants

Timeline

Start Date

March 3, 2022

Primary Completion Date

May 21, 2026

Study Completion Date

May 21, 2027

Conditions
Prostate Cancer RecurrentSolid Tumor, Adult
Interventions
COMBINATION_PRODUCT

Hydroxychloroquine, Metformin, Sirolimus

Hydroxychloroquine 600mg twice daily Metformin 500mg daily for 7 days, then increase to 1000mg daily Sirolimus 0.5mg daily

COMBINATION_PRODUCT

Hydroxychloroquine, Metformin, Sirolimus, Dasatanib

Hydroxychloroquine 600mg twice daily Metformin 500mg daily for 7 days, then increase to 1000mg daily Sirolimus 0.5mg daily Dasatinib 20mg daily

COMBINATION_PRODUCT

Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir

Hydroxychloroquine 600mg twice daily Metformin 500mg daily for 7 days, then increase to 1000mg daily Sirolimus 0.5mg daily Nelfinavir 1250mg twice daily

COMBINATION_PRODUCT

Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir, Dasatinib

Hydroxychloroquine 600mg twice daily Metformin 500mg daily for 7 days, then increase to 1000mg daily Sirolimus 0.5mg daily Nelfinavir 1250mg twice daily Dasatanib 20mg daily

COMBINATION_PRODUCT

Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir

Hydroxychloroquine 600mg twice daily Metformin 500mg daily for 7 days, then increase to 1000mg daily Sirolimus 0.5mg daily Nelfinavir 2500mg twice daily

COMBINATION_PRODUCT

Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir, Dasatinib

Hydroxychloroquine 600mg twice daily Metformin 500mg daily for 7 days, then increase to 1000mg daily Sirolimus 0.5mg daily Nelfinavir 2500mg twice daily Dasatanib 20mg daily

Trial Locations (1)

29425

RECRUITING

Medical University of South Carolina, Charleston

All Listed Sponsors
lead

Medical University of South Carolina

OTHER