Synaptic Plasticity in the Epicardial Ganglionated Plexi

PHASE1RecruitingINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

March 24, 2021

Primary Completion Date

October 31, 2024

Study Completion Date

December 31, 2024

Conditions
Atrial Fibrillation
Interventions
DEVICE

Parasym

Stimulation will be done under anesthesia for 30 minutes. Stimulation parameters include a pulse width of 200 μs, amplitude of 20 mA and a pulse frequency of 20 Hz. The Parasym devise (Parasym Health, London, UK) will be used for stimulation. The device will be connected to a clip electrode that will be attached to the external ear. In the active group, the ear clip electrode will be attached to tragus in the active stimulation group. This device has been deemed non-significant risk by the FDA. In the control group, no stimulation will be done.

DEVICE

Sham stimulation

Sham stimulation

Trial Locations (1)

73104

RECRUITING

OU Medical Center, Oklahoma City

All Listed Sponsors
lead

University of Oklahoma

OTHER