A Study of IBI110 in Combination With Sintilimab and Chemotherapy in Patients With Untreated Extensive-Stage Small Cell Lung Cancer

PHASE1CompletedINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

September 7, 2021

Primary Completion Date

February 16, 2023

Study Completion Date

June 26, 2023

Conditions
SCLC
Interventions
DRUG

Carboplatin

Carboplatin will be administered after completion of Sintilimab by IV infusion to achieve an initial target AUC of 5 mg/mL/min on Day 1.

DRUG

Cisplatin

Cisplatin 75 mg/m\^2 will be administered after completion of Sintilimab by IV infusion on Day 1.

DRUG

Etoposide

Etoposide 100 mg/m\^2 will be administered by IV infusion following carboplatin or cisplatin administration, during the induction phase on Day 1 through 3 of each cycle. On Days 2 and 3, patients will receive etoposide alone.

DRUG

Sintilimab

Sintilimab 200 mg will be administered by IV infusion following IBI110 on Day 1 of each 21-day .

DRUG

IBI110

IBI110 RP2D will be administered by IV infusion on Day 1 of each 21-day .

Trial Locations (1)

NO.507,Zhengmin Road,Yangpu

Shanghai Pulmonary Hospital, Shanghai

All Listed Sponsors
lead

Innovent Biologics (Suzhou) Co. Ltd.

INDUSTRY

NCT05026593 - A Study of IBI110 in Combination With Sintilimab and Chemotherapy in Patients With Untreated Extensive-Stage Small Cell Lung Cancer | Biotech Hunter | Biotech Hunter