1,125
Participants
Start Date
November 18, 2021
Primary Completion Date
December 30, 2024
Study Completion Date
December 30, 2024
Simufilam
Simufilam is a novel drug candidate designed to treat and slow the progression of AD. Simufilam binds with femtomolar affinity to an altered conformation of filamin A that is present in the brain of patients with AD and critical to the toxicity of Aβ42. In this study, simufilam will be given b.i.d. for 76 weeks at a dose of 50 mg or 100 mg.
Placebo
Matching placebo given b.i.d. for 76 weeks
Richmond Behavioral Associates, Staten Island
Integrative Clinical Trials, Brooklyn
SPRI Clinical Trials Brooklyn, Brooklyn
Hanyang University Guri Hospital, Guri-si
Albany Medical Center, Albany
Neurological Associates of Albany, Albany
Velocity Clinical Research, Formerly Clarity Clinical Research, East Syracuse
Seoul National University Bundang Hospital, Seongnam-si
The Clinical Trial Center, Jenkintown
Keystone Clinical Studies, LLC, Plymouth Meeting
Gachon University Gil Hospital, Namdong-gu
Inha University Medical Center, Incheon
Accellacare Research of Winston-Salem, Winston-Salem
Accel Research Sites - NeuroStudies, Decatur
Columbus Memory Center, PC, Columbus
K2 Medical Research, Maitland
Conquest Research, Winter Park
Clinical Neuroscience Solutions, Inc. dba CNS Healthcare, Orlando
Indago Research and Health Center, Inc., Hialeah
Mind Institute at Miami Jewish Health, Miami
Brainstorm Research, Miami
Alzheimer's Research & Treatment Center, Wellington
Quantum Laboratories, Deerfield Beach
Brain Matters Research Inc, Delray Beach
Alphab Global Research, Jupiter
JEM Research Institute, Atlantis
Parkinson's Disease and Movement Disorders Center of Boca Raton, Boca Raton
Clinical Research of Brandon, LLC, Brandon
USF Health - Byrd Alzheimer's Center and Research Institute, Tampa
Intercoastal Medical Group - Sarasota, Sarasota
Health Synergy Clinical Research, Okeechobee
Alzheimer's Research & Treatment Center, Stuart
Brain Matters Research Inc, Stuart
KCA Neurology, PLLC, Franklin
University of Kentucky Sanders-Brown Center on Aging, Lexington
Ohio State University, Columbus
Neuro-Behavioral Clinical Research (NBCR), North Canton
Neurology Diagnostics, Dayton
Medical College of Wisconsin, Milwaukee
Advocate Aurora Health, Park Ridge
Great Lakes Clinical Trials, Chicago
Chonnam National University Hospital, Gwangju
Kyungpook National University Chilgok Hospital, Daegu
Cedar Health Research, Irving
Neurology Consultants of Dallas, PA, Dallas
Banner Alzheimer's Institute, Phoenix
Arizona Neuroscience Research, LLC, Phoenix
Clinical Endpoints, Scottsdale
Banner Sun Health Research Institute, Sun City
Banner Alzheimer's Institute - Tucson, Tucson
California Research Insitute, Los Angeles
Healthy Brain Clinic, Long Beach
North County Neurology Associates, Carlsbad
Pacific Research Network, LLC, San Diego
Shankle Clinic and Hoag Memorial Hospital Presbyterian, Newport Beach
Neurology Center of North Orange County, Fullerton
Neuro-Pain Medical Center, Fresno
Center for Cognitive Health - Portland, Portland
Northwest Clinical Research Center, Bellevue
Nuvance Health Medical Practice CT, Inc. - Associated Neurologists, PC, Danbury
Ki Health Partners, LLC, Stamford
Neurology Center of New England, Foxborough
ActivMed Practices & Research, LLC, Methuen
Boston Center for Memory, Newton
Office of Donald S. Marks, M.D., P.C., Plymouth
MedVadis Research, Waltham
Patient First MD, Middletown
Global Medical Institutes, LLC, Princeton
The Cognitive and Research Center of New Jersey (CRCNJ), Springfield
Advanced Memory Research Institute of NJ, Toms River
The Memory Clinic - Bennington, Bennington
OCT Research ULC DBA Okanagan Clinical Trials, Kelowna
Djavad Mowafaghian Centre for Brain Health, Vancouver
Centre Hospitalier Universitaire Dr-Georges-L.-Dumont (CHUDGLD), Moncton
True North Clinical Research - Halifax, Halifax
True North Clinical Research - New Minas, New Minas
St. Joseph's Health Care London, London
Ottawa Memory Clinic, Ottawa
Recherches Neuro-Hippocampe Inc., Ottawa
Kawartha Centre - Redefining Healthy Aging, Peterborough
Toronto Memory Program, Toronto
The Centre for Memory and Aging, Toronto
Instituto De Neurologia Dra. Ivonne Fraga, San Juan
Santa Cruz Behavioral PSC, Bayamón
Inspira Clinical Research, San Juan
Barbara Diaz Hernandez Md Research, Inc., San Juan
Korea University Anam Hospital, Seongbuk-gu
HanYang University Hospital, Seongdong-gu
Asan Medical Center, Seoul
Lead Sponsor
Collaborators (1)
Premier Research Group plc
UNKNOWN
Cassava Sciences, Inc.
INDUSTRY