NeoAdjuvant Pembrolizumab and STEreotactic Radiotherapy Prior to Nephrectomy for Renal Cell Carcinoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

February 8, 2022

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Renal Cell Carcinoma, Clear Cell, Somatic
Interventions
DRUG

Pembrolizumab

Pembrolizumab 200 mg tobe administered as a 30 minute IV infusion every 21 days for 3 cycles

RADIATION

Stereotactic Ablative Radiotherapy

42Gy delivered in 3 fractions

PROCEDURE

Nephrectomy

Partial or total nephrectomy performed 9-12 weeks after first dose of Pembrolizumab

Trial Locations (2)

3000

RECRUITING

Peter MacCallum Cancer Centre, Melbourne

4102

RECRUITING

Princess Alexandra Hospital, Woolloongabba

All Listed Sponsors
lead

Peter MacCallum Cancer Centre, Australia

OTHER