12
Participants
Start Date
October 4, 2021
Primary Completion Date
November 15, 2024
Study Completion Date
November 30, 2025
High-Frequency-Only Stimulation
Control condition, constant high-frequency DBS stimulation (130Hz)
Low-Frequency-Only Stimulation
Experimental condition, constant low-frequency DBS stimulation (60 Hz)
Alternating, 50 sec High-Frequency, 10 sec Low-Frequency Stimulation
Experimental condition where stimulation frequency is changed from high (130Hz) to low (60Hz) frequency. The time interval for each frequency is 50 seconds for high, and 10 seconds for low, respectively.
Alternating, 50 sec High-Frequency, 50 sec Low-Frequency Stimulation
Experimental condition where stimulation frequency is changed from high (130Hz) to low (60Hz) frequency. The time interval for each frequency is 50 seconds for high, and 50 seconds for low, respectively.
Alternating, 10 sec High-Frequency, 50 sec Low-Frequency Stimulation
Experimental condition where stimulation frequency is changed from high (130Hz) to low (60Hz) frequency. The time interval for each frequency is 10 seconds for high, and 50 seconds for low, respectively.
Alternating, 10 sec High-Frequency, 10 sec Low-Frequency Stimulation
Experimental condition where stimulation frequency is changed from high (130Hz) to low (60Hz) frequency. The time interval for each frequency is 10 seconds for high, and 10 seconds for low, respectively.
OFF Dopaminergic Medication
All six device interventions will be performed in medication OFF state
ON Dopaminergic Medication
All six device interventions will be performed in medication ON state
Cleveland Clinic Foundation, Cleveland
James Liao
OTHER