Ociperlimab With Tislelizumab and Chemotherapy in Participants With Untreated Metastatic Non-Small Cell Lung Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

272

Participants

Timeline

Start Date

November 16, 2021

Primary Completion Date

September 4, 2024

Study Completion Date

September 4, 2024

Conditions
Locally Advanced, Unresectable, or Metastatic Nonsmall Cell Lung Cancer (NSCLC)Nonsmall Cell Lung Cancer, Stage IIIBNonsmall Cell Lung Cancer, Stage IV
Interventions
DRUG

Ociperlimab

900 mg intravenously (IV) once every 3 weeks (Q3W)

DRUG

Tislelizumab

200 mg IV Q3W

DRUG

Carboplatin

Area under the concentration-time curve (AUC) of 5 or 6, administered on Day 1 of each 21-day cycle

DRUG

Paclitaxel

75 or 200 mg per square meter (mg/m²) of body surface area, administered on Day 1 of each 21-day cycle

DRUG

Nab paclitaxel

100 mg/m², administered intravenously on Days 1, 8, and 15 of each 21-day cycle

DRUG

Cisplatin

75 mg/m², administered intravenously on Day 1 of each 21-day cycle

DRUG

Pemetrexed

500 mg/m² administered intravenously on Day 1 of each 21-day cycle

DRUG

Placebo

Administered intravenously Q3W to match ociperlimab

Trial Locations (64)

1140

Klinik Penzing Wien, Abteilung Fur Atemwegs, Vienna

2086

Northern Beaches Hospital, Frenchs Forest

2444

Port Macquarie Base Hospital, Port Macquarie

2640

Border Medical Oncology, East Albury

3084

Olivia Newton John Cancer Wellness and Research Centre, Heidelberg

3199

Peninsula and South Eastern Haematology and Oncology Group, Frankston

4350

Toowoomba Hospital, Toowoomba

4814

Townsville University Hospital, Douglas

7250

Launceston General Hospital, Launceston

13496

Cha Bundang Medical Center, Cha University, BundangGu SeongnamSi

14000

Centre Hospitalier Regional Universitaire de Caen, Caen

15009

Centro Oncologico de Galicia, A Coruña

16499

Ajou University Hospital, Suwon

24071

Complejo Asistencial Universitario de Leon, León

33011

Hospital Universitario Central de Asturias, Oviedo

44033

Ulsan University Hospital, Donggu

46009

Fundacion Instituto Valenciano de Oncologia Ivo, Valencia

49201

Dong A University Hospital, Seogu

50009

Ch Provincial de Castellon, Castellon

55236

St Lukes Hospital, Thessaloniki

75005

Institut Curie, Paris

75015

Hopital Europeen Georges Pompidou, Paris

76000

Hopital Charles Nicolle Clinique Pneumologique, Rouen

100142

Beijing Cancer Hospital, Beijing

114000

Ansteel Group General Hospital, Anshan

150000

Harbin Medical University Cancer Hospital, Harbin

200000

Fudan University Shanghai Cancer Center, Shanghai

200040

Huashan Hospital Affiliated to Fudan University, Shanghai

200433

Shanghai Pulmonary Hospital, Shanghai

213001

Changzhou Cancer Hospital, Changzhou

250117

Shandong Cancer Hospital, Jinan

252000

Liaocheng Peoples Hospital, Liaocheng

310014

Zhejiang Provincial Peoples Hospital, Hangzhou

310022

Zhejiang Cancer Hospital, Hangzhou

313003

Huzhou Central Hospital, Huzhou

314001

The First Hospital of Jiaxing, Jiaxing

321000

Jinhua Municipal Central Hospital, Jinhua

350014

Fujian Cancer Hospital, Fuzhou

400037

Xinqiao Hospital Affiliated to the Army Medical University, Chongqing

400042

Daping Hospital, Third Military Medical University, Chongqing

423000

The First Peoples Hospital of Chenzhou, Chenzhou

434020

Jingzhou Central Hospital, Jingzhou

450052

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

510030

Cancer Center of Guangzhou Medical University, Guangzhou

610041

West China Hospital, Sichuan University, Chengdu

730000

The First Hospital of Lanzhou University, Lanzhou

844099

The First Peoples Hospital of Kashgar, Kashgar

90067-2011

Valkyrie Clinical Trials, Los Angeles

52242-1009

University of Iowa Hospitals and Clinics, Iowa City

89169-3321

Comprehensive Cancer Center of Nevada, Las Vegas

11042-1118

Rj Zuckerberg Cancer Center, New Hyde Park

10028-0517

North Shore Hematology Oncology Associates Dba New York Cancer and Blood Specialists (New York), New York

11776-8066

North Shore Hematology Oncology Associates Dba New York Cancer and Blood Specialists, Port Jefferson Station

10469-5930

Ny Cancer and Blood Specialists, The Bronx

45409-1328

Xcancerdayton Physician Network, Dayton

37909-1327

Tennessee Cancer Specialist, Knoxville

78705-1163

Texas Oncology Tyler Longview, Austin

99216-1020

Cancer Care Northwest, Spokane Valley

06351

Samsung Medical Center, GangnamGu

08308

Korea University Guro Hospital, GuroGu

03181

Kangbuk Samsung Hospital, JongnoGu

03722

Severance Hospital Yonsei University Health System, SeodaemunGu

03080

Seoul National University Hospital, Seoul

06273

Gangnam Severance Hospital, Yonsei University Health System, Seoul

Sponsors

Lead Sponsor

All Listed Sponsors
lead

BeiGene

INDUSTRY