The Simplify Project

RecruitingOBSERVATIONAL
Enrollment

50

Participants

Timeline

Start Date

September 1, 2021

Primary Completion Date

July 1, 2026

Study Completion Date

July 1, 2026

Conditions
Acute Hypercapnic Respiratory Failure
Interventions
DEVICE

High-flow nasal cannula therapy

High-flow nasal cannula therapy (HFNC) (from 25 - 60 L/min based on patient's tolerance) will be used in 21 participants during one additional sleep study to investigate its acute impact on reducing sleep abnormalities. Inspired fraction of oxygen will be titrated to maintain patient SpO2 similar to the levels during standard oxygen therapy.

Trial Locations (1)

M5B 1W8

RECRUITING

St. Michael's Hospital, Toronto

All Listed Sponsors
lead

Unity Health Toronto

OTHER