A Study to Determine the Safety, Pharmacokinetics, and Pharmacodynamics of DNL343 in Participants With Amyotrophic Lateral Sclerosis

PHASE1CompletedINTERVENTIONAL
Enrollment

29

Participants

Timeline

Start Date

August 11, 2021

Primary Completion Date

December 15, 2022

Study Completion Date

June 5, 2024

Conditions
Amyotrophic Lateral Sclerosis
Interventions
DRUG

DNL343

Oral repeating dose

DRUG

Placebo

Oral repeating dose

Trial Locations (7)

2333

Centre for Human Drug Research (CHDR), Leiden

28207

Atrium Health Neurosciences Institute, Charlotte

30322

Emory University, Atlanta

32806

PPD Orlando, Orlando

85251

HonorHealth, Scottsdale

92093

University of California at San Diego, San Diego

94115

California Pacific Medical Center, San Francisco

Sponsors
All Listed Sponsors
lead

Denali Therapeutics Inc.

INDUSTRY