Acalabrutinib and Rituximab in Previously Untreated Mantle Cell Lymphoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

November 30, 2023

Primary Completion Date

November 30, 2026

Study Completion Date

December 1, 2028

Conditions
Mantle Cell Lymphoma
Interventions
DRUG

Acalabrutinib

Patients will receive acalabrutinib 100mg twice daily for up to six 28 day cycles. Patients can receive 100mg once daily for cycle 1, day 1 to day 7, according to the investigator's discretion.

DRUG

Rituximab

Patient will receive rituximab 375 mg/m2 IV on day 1 (+/- 3 days) of each cycle, for a maximum of 6 cycles

Trial Locations (12)

Unknown

RECRUITING

The Royal Bournemouth Hospital, Bournemouth

RECRUITING

University Hospital of Wales, Cardiff

RECRUITING

Royal Cornwall Hospital, Cornwall

RECRUITING

Beatson West of Scotland Cancer Centre, Glasgow

RECRUITING

St. Bartholomew's Hospital, London

RECRUITING

University College London Hospital, London

RECRUITING

The Christie Hospital, Manchester

RECRUITING

Clatterbridge Cancer Centre, Metropolitan Borough of Wirral

RECRUITING

Norfolk and Norwich University Hospital, Norwich

RECRUITING

Cancer and Haematology Centre, Churchill Hospital, Oxford

RECRUITING

Derriford Hospital, Plymouth

RECRUITING

Royal Stoke Hospital, Stoke-on-Trent

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

lead

University College, London

OTHER