Left vs. Right Non-Inferiority Trial

NARecruitingINTERVENTIONAL
Enrollment

420

Participants

Timeline

Start Date

November 8, 2021

Primary Completion Date

February 1, 2026

Study Completion Date

February 1, 2026

Conditions
DepressionMajor Depressive DisorderMajor Depressive Episode
Interventions
DEVICE

Repetitive Transcranial Magnetic Stimulation

rTMS will employ the MagPro X100/R30 stimulator equipped with the cool-B70 as we used a cool-B70 in our past non-inferiority trial. The dose will be a 120% rMT in accordance to our latest trial using iTBS. The target area to stimulate will be the right dorsolateral prefrontal cortex (DLPFC) for LFR and the left DLPFC for iTBS as established in prior clinical trials. The localization of both targets will follow the well-established procedures for either R-DLPFC or L-DLPFC using a heuristic method.

DEVICE

Intermittent Theta Burst Stimulation (iTBS)

Intermittent Theta Burst Stimulation (iTBS)

DEVICE

Low Frequency Right (LFR)

Low Frequency Right (LFR)

Trial Locations (2)

V6T 2A1

RECRUITING

Non-Invasive Neurostimulation Therapies Centre, University of British Columbia, Vancouver

M6J 1H4

RECRUITING

Centre for Addiction and Mental Health, Toronto

All Listed Sponsors
collaborator

Centre for Addiction and Mental Health

OTHER

lead

University of British Columbia

OTHER