A Research Study to Investigate How Well NNC0165-1875 in Combination With Semaglutide Works in People With Obesity

PHASE2CompletedINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

July 15, 2021

Primary Completion Date

December 6, 2022

Study Completion Date

January 30, 2023

Conditions
Obesity
Interventions
DRUG

Semaglutide 2.4 mg and NNC0165-1875 2.0 mg

NNC0165-1875 will be co-escalated once-weekly subcutaneously with semaglutide every 2 weeks for the first 4 weeks, and every 4 weeks for the next 8 weeks until final target dose levels are reached.

DRUG

Semaglutide 2.4 mg and placebo 2.0 mg

NNC0165-1875 placebo will be co-escalated subcutaneously once-weekly with semaglutide every 2 weeks for the first 4 weeks, and every 4 weeks for the next 8 weeks until final target dose levels are reached.

DRUG

Semaglutide 2.4 mg and NNC0165-1875 1.0 mg

NNC0165-1875 will be co-escalated subcutaneously once-weekly with semaglutide every 2 weeks for the first 4 weeks, and every 4 weeks for the next 8 weeks until final target dose levels are reached.

DRUG

Semaglutide 2.4 mg and placebo 1.0 mg

NNC0165-1875 placebo will be co-escalated subcutaneously once-weekly with semaglutide every 2 weeks for the first 4 weeks, and every 4 weeks for the next 8 weeks until final target dose levels are reached.

Trial Locations (14)

23294

National Clin Res Inc., Richmond

23606

Health Res of Hampton Roads, Newport News

28401

Accellacare, Wilmington

29405

Coastal Carolina Res Ctr., North Charleston

29425

Medical Uni of SC Charleston, Charleston

30076

Endo Res Solutions Inc, Roswell

32216

Jacksonville Ctr For Clin Res, Jacksonville

40213

L-MARC Research Center, Louisville

60077

Evanston Premier Hlthcr Res, Skokie

66212

Altasciences Clinical Kansas, Inc., Overland Park

75226

Soltero Cardiovascular Research Center, Dallas

84790

Chrysalis Clinical Research, St. George

94598

Diablo Clinical Research, Inc., Walnut Creek

96814

East West Med Res Inst, Honolulu

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Novo Nordisk A/S

INDUSTRY