Treatment of Newly Diagnosed Patient's With Wilm's Tumor Requiring Abdominal Radiation Delivered With Proton Beam Irradiation

PHASE2RecruitingINTERVENTIONAL
Enrollment

95

Participants

Timeline

Start Date

August 19, 2021

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2036

Conditions
Wilms Tumor
Interventions
DEVICE

Proton Beam Radiation (PBRT)

The treatment approach with radiation therapy prescribed in this trial is designed to deliver highly conformal radiation therapy (proton beam radiation or intensity modulated photon radiation) to target volumes that are based on the burden of disease.

DRUG

DD-4A Chemotherapy Regimen

Patients will receive standard of care chemotherapy based on diagnosis and stage.

PROCEDURE

Complete Surgical Resection

Participants will undergo complete surgical resection at diagnosis or after 6-12 weeks of induction chemotherapy

PROCEDURE

Surgical Resection

Participants will undergo surgical resection at diagnosis or after 6-12 weeks of induction chemotherapy.

PROCEDURE

Partial Nephrectomy

Participants will undergo partial nephrectomy after 6-12 weeks of induction chemotherapy.

Trial Locations (1)

38105

RECRUITING

St.Jude Children's Research Hospital, Memphis

All Listed Sponsors
lead

St. Jude Children's Research Hospital

OTHER