A Study to Evaluate the Efficacy and Safety of Intravitreal KSI-301 Compared With Intravitreal Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD)

PHASE3CompletedINTERVENTIONAL
Enrollment

557

Participants

Timeline

Start Date

June 23, 2021

Primary Completion Date

March 28, 2023

Study Completion Date

April 6, 2023

Conditions
Wet Age-related Macular Degeneration
Interventions
DRUG

KSI-301

Intravitreal Injection

DRUG

Aflibercept

Intravitreal Injection

OTHER

Sham Procedure

The sham is a procedure that mimics an intravitreal injection. It involves pressing the blunt end of an empty syringe (without a needle) against the anesthetized eye. It will be administered to participants in both treatments arms at applicable visits to maintain masking.

Trial Locations (66)

13088

Retina-Vitreous Surgeons of Central NY, Liverpool

14620

Retina Associates of Western NY, Rochester

19107

MidAtlantic Retina, Philadelphia

20815

Retina Group of Washington, Chevy Chase

21740

Cumberland Valley Retina Consultants PC, Hagerstown

28803

Western Carolina Retinal Associate PA, Asheville

29456

Charleston Neuroscience Institute, Ladson

29902

Retina Research of Beaufort, Beaufort

30909

Southeast Retina Center, Augusta

32503

Retina Specialty Institute, Pensacola

32901

Florida Eye Associates, Melbourne

33064

Rand Eye Institute, Deerfield Beach

33426

Florida Eye Microsurgical Institute, Boynton Beach

33609

Retina Associates of Florida, Tampa

33703

Retina Vitreous Associates of Florida, St. Petersburg

33907

Retina Health Center, Fort Myers

33912

National Ophthalmic Research Institute, Fort Myers

37203

Tennessee Retina PC, Nashville

37909

Southeastern Retina Associates PC, Knoxville

40509

Retina Associates of Kentucky, Lexington

44130

Retina Associates of Cleveland, Cleveland

44195

Cleveland Clinic Foundation, Cole Eye Institute, Cleveland

47710

Talley Eye, Evansville

49525

Foundation for Vision Research, Grand Rapids

50266

Wolfe Eye Clinic, West Des Moines

55435

Vitreoretinal Surgery PA, Edina

57701

Black Hills Regional Eye Institute, Rapid City

60637

University of Chicago, Chicago

62703

Springfield Clinic LLP, Springfield

66215

Retina Associates PA, Lenexa

72762

Northwest Arkansas Retina Associates, Springdale

75075

Texas Retina Associates, Plano

76087

Strategic Clinical Research Group, LLC, Willow Park

77030

Retina Consultants of Texas, Houston

77384

Retina Consultants of Texas - (Woodlands), The Woodlands

77494

Retina Consultants of Texas-(Katy), Katy

78073

Associated Retinal Consultants PC, Royal Oak

78240

Medical Center Ophthalmology Associates, San Antonio

78681

Austin Retina Associates (Round Rock), Round Rock

78705

Austin Retina Associates, Austin

79606

Retina Research Institute of Texas, Abilene

80228

Colorado Retina Associates PC, Lakewood

85014

Retinal Research Institute, LLC, Phoenix

89502

Sierra Eye Associates, Reno

92037

UCSD Jacobs Retina Center, La Jolla

92064

Retina Consultants of San Diego, Poway

92374

Retina Consultants of Southern California, Redlands

92653

Retina Associates of Orange County, Laguna Hills

92705

Orange County Retina Medical Group, Santa Ana

92835

Retina Consultants of Orange County, Fullerton

93309

California Retina Consultants, Bakersfield

93720

Eye Medical Center of Fresno, Fresno

94040

Northern California Retina Vitreous Associates, Mountain View

95819

Retinal Consultants Medical Group Inc, Sacramento

97210

Retina Northwest, Portland

97302

Retina Consultants, LLC, Salem

97477

Cascade Medical Research Institute, Springfield

99204

Spokane Eye, Spokane

296169

Palmetto Retina Center, West Columbia

06385

Retina Group of New England, Waterford

02114

Ophthalmic Consultants of Boston, Boston

01103

New England Retina Consultants, Springfield

01603

Vitreo Retinal Associates PC, Worcester

07017

The Retina Center of New Jersey, Bloomfield

07605

NJ Retina, Teaneck

00612

Emanuelli Research & Development Center LLC, Arecibo

Sponsors
All Listed Sponsors
lead

Kodiak Sciences Inc

INDUSTRY

NCT04964089 - A Study to Evaluate the Efficacy and Safety of Intravitreal KSI-301 Compared With Intravitreal Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD) | Biotech Hunter | Biotech Hunter