Drug-Drug Interaction Study Assessing Effect of Carbamazepine on PF-07321332 Boosted With Ritonavir

PHASE1CompletedINTERVENTIONAL
Enrollment

12

Participants

Timeline

Start Date

July 15, 2021

Primary Completion Date

October 9, 2021

Study Completion Date

October 9, 2021

Conditions
Healthy Participant
Interventions
DRUG

PF-07321332/ritonavir

PF-07321332/ritonavir administered orally as a single dose on Day 1, Period 1

DRUG

Carbamazepine

In Period 2, Days 1-3, participants will receive low-dose of carbamazepine twice daily (BID), then a titrated mid-dose of carbamazepine BID on Days 4-7, and finally maintaining carbamazepine at the high-dose on Days 8-15.

DRUG

PF 07321332/ritonavir

In Period 2, Day 14, participants will receive a single dose of PF-07321332/ritonavir orally.

Trial Locations (1)

06511

Pfizer New Haven Clinical Research Unit, New Haven

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY