Frontline Treatment of Follicular Lymphoma With AtezolizUmab and Obinutuzumab With and Without RadiOtherapy

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

15

Participants

Timeline

Start Date

August 17, 2021

Primary Completion Date

April 30, 2023

Study Completion Date

July 31, 2025

Conditions
Follicular Lymphoma
Interventions
DRUG

Obinutuzumab 25 MG/1 ML Intravenous Solution

"For intravenous infusion during:~Induction phase: Day 1, 8 and 15 of cycle 1 \& Day 1 of cycle 2-6 (q3/52); Maintenance phase: Day 1 of each cycle (q8/52) for up to 12 cycles."

DRUG

Atezolizumab 1200 MG/40mL Intravenous Solution

For intravenous infusion during induction phase only day 1 of each cycle q3/52 for up to 6 cycles.

RADIATION

4 Gy in 2 fractions

Involved site radiotherapy will only be administered to participants to achieve a PR/SD after at restaging after cycle 2, treatment will be between cycle 3 and 4 of induction treatment.

Trial Locations (3)

3078

Austin Health, Heidelberg

3128

Eastern Health, Box Hill

Unknown

Ballarat Health Service, Ballarat

Sponsors
All Listed Sponsors
collaborator

Roche Products Pty Limited

UNKNOWN

collaborator

Austin Health

OTHER_GOV

collaborator

Ballarat Health Services

OTHER

lead

Olivia Newton-John Cancer Research Institute

OTHER