Orelabrutinib, Sintilimab and Temozolomide in Relapsed or Refractory Central Nervous System Lymphoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

19

Participants

Timeline

Start Date

July 1, 2021

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2026

Conditions
Primary Central Nervous System Hodgkin Lymphoma
Interventions
DRUG

Orelabrutinib

Orelabrutinib: 150 mg orally once daily

DRUG

Sintilimab

Sintilimab: 200 mg intravenously every 3 weeks

DRUG

Temozolomide (TMZ)

Temozolomide: 150 mg/m² orally on days 1-5 of each 21-day cycle

Trial Locations (1)

310009

RECRUITING

2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou

All Listed Sponsors
collaborator

Sir Run Run Shaw Hospital

OTHER

collaborator

First Affiliated Hospital of Zhejiang University

OTHER

collaborator

Wenzhou Central Hospital

OTHER

collaborator

Second Affiliated Hospital of Wenzhou Medical University

OTHER

collaborator

Zhejiang Provincial Tongde Hospital

OTHER

collaborator

First People's Hospital of Hangzhou

OTHER

collaborator

Zhejiang Provincial People's Hospital

OTHER

collaborator

Jinhua Central Hospital

OTHER

collaborator

Jinhua People's Hospital

OTHER

collaborator

Yinzhou Hospital Affiliated to Medical School of Ningbo University

OTHER

collaborator

Huzhou Central Hospital

OTHER

lead

Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER