250
Participants
Start Date
April 19, 2022
Primary Completion Date
May 31, 2026
Study Completion Date
November 30, 2026
Cognitive Behavioral Therapy
The CBT intervention is based on the theoretical framework that under stress (reflux symptoms) a person makes a rapid cognitive appraisal of the potential threat (automatic thoughts), leading to both emotional and physical responses in the body, thereby reacting behaviorally (avoidance, increased HCU) in an attempt to mitigate unpleasantness. CBT is a collaborative, present-focused treatment that utilizes a skills-based approach with home practice exercises. CBT targets automatic thoughts and appraisals of threat via education, self-monitoring of stressors and symptoms, and strategies to reframe problematic thinking patterns to more adaptive ones. Resonance frequency breathing (RFB) is achieved when a person breathes at a pace, typically 4 to 6 breaths per minute, that engages the body's baroreflex to modulate arousal. Prior research demonstrates 4 to 6 weeks of RFB training is sufficient to significantly increase baseline HRV with enduring effects for up to 6 months.
Sham-SOC Lifestyle Coaching
Sham-SOC Lifestyle Coaching
Northwestern University, Chicago
Washington University, St Louis
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Washington University School of Medicine
OTHER
University of California, San Diego
OTHER
Vanderbilt University School of Medicine
OTHER
Northwestern University
OTHER